Man-of-the-match Griezmann strikes twice for Atletico while Marseille lost captain Payet to injury after 30 minutes
Wednesday night's clash sees the French club return from a more than 20-year cup final wilderness, while Atletico are seeking their third title this decade.
Excitement builds in Lyon's City Centre for tonight's showdown between Atletico Madrid and Marseille, where two of Europe's footballing legends give their predictions.
Olympique Marseille face Atletico Madrid in the showpiece event with hundreds of policemen and extra security measures deployed to prevent fans clashing outside the stadium and around the city.
Arsenal host Atletico Madrid in the Europa league semi-final first leg at the Emirates Stadium.
Lyon got to have a close-up look at the Europa League trophy when former Barcelona and French international football player Eric Abidal posed with cup at the Gadagne Museum, fresh from making the draw for the semi final.
More comebacks, this time in the Europa League, as Arsenal, Marseille, Red Bull Salzburg and Atletico Madrid book their place in the last four.
Arsenal's Laurent Koscielny, Nacho Monreal, Aaron Ramsey and Mesut Ozi were rested for the Gunners' last game and are expected to feature against CSKA Moscow.
Arsenal draw CSKA in Europa league.
The officer reportedly had a heart attack after being hit by a flare in violent clashes between Spartak Moscow and Athletic Bilbao fans
Evra has been summoned to an interview that will lead to disciplinary action
Manchester United gave its grieving home city a cause for cheer by winning their first Europa League trophy.
Manchester United and Ajax are in Stockholm for the Europa League final
Manchester United survived a late scare to draw at home to Celta Vigo and reach the Europa League final on Thursday.
English giants Manchester United will play Ajax in the Stockholm final after both teams qualified
Marcus Rashford's free kick in the 67th minute gave Manchester United a 1-0 win over the Spaniards
Ajax beat Lyon 4-1 in the first leg of their Europa League semi-final, but will the French side's away goal prove crucial when the two sides meet again in France?
Manchester United, Ajax, Celta Vigo and Lyon reach the semi-finals of the Europa League
Manchester United are tied 1-1 with Anderlecht as they go into their Old Trafford leg
Crowd trouble delays Lyon match-Man United draw with Anderlecht
Man United face Anderlecht in Brussels in the Europa League
The Europa League gets down to the last eight sides, and Man United is one of them.
All the scores from the Europa League last 16
Jose Mourinho is not happy about the state of the pitch but the game is going ahead nonetheless as Manchester United make the trip to Rostov for the first leg of their Europa League last 16…
French fans went into ecstasy after beating Ireland and making it through to the quarter finals.