Sevilla vs. Manchester United
The Champions League Round of Last 16 continues with Sevilla hosting Manchester United at the Estadio Ramon Sanchez Pizjua.
The Spanish side were knocked out at this stage last season by Leicester City and have never before reached the Quarter Finals.
They have a triple injury boost with Ever Banega, Joaquin Correa and Nolito all fit following lay-offs.
Manchester United travel to Spain dreaming of Champions League glory with their hopes of catching Manchester City in the Premier League all but over.
They're boosted by the return of Paul Pogba who missed their weekend's FA Cup victory at Huddersfield through illness. Goalkeeper David De Gea is also expected to return, while Marcus Rashford, Ander Herrera and Antonio Valencia have a chance of playing.
Zlatan Ibrahimovic is still sidelned despite a return to training. Marcos Rojo, Phil Jones and Marouane Fellaini are also likely to miss out.
Three-time European champions United are back in the Champions League knock-out rounds for the first time since 2014 after winning Group A. Manager Jose Mourinho is looking to win the competition for a third time after previous successes with Porto in 2004 and Inter Milan in 2010.
The two teams have met just once before, in a pre-season friendly at Old Trafford in 2013.
Shakhtar Donetsk vs. Roma
In the other Last 16 fixture, Roma travel to Ukraine to face Shakhtar Donetsk.
The Italians have won their last three matches and are up to third in Serie A behind leaders leaders Napoli and Juventus.
Roma's stand-out performer of recent weeks is Turkish winger Cengiz Under, who scored his fourth goal of his last three games during Saturday's 2-0 win at Udinese.
The Italians' good form is in contrast to their opponents Shakhtar, who have only played once since returning from a Winter break in their domestic league.
Shakhtar skipper Darijo Srna is serving a suspension for a failed drugs test, but otherwise the Ukrainians are at full-strength.
Meanwhile, Roma will be without Rick Karsdorp (knee), Maxime Gonalons (calf) and Luca Pellegrini (knee), with Alessandro Florenzi also a doubt due to illness.