Former Formula 1 World Champion Fernando Alonso is to race in the Indianapolis 500.
The McLaren driver will miss the Monaco Grand Prix.
The manufacturer has yet to decide who will replace the Spaniard in Monaco, though Jenson Button is in the frame.
Button has retired, but works as an ambassador for McLaren.
Alonso will race for the McLaren branded, Honda-powered Andretti team on 28 May.
The Spaniard has long held a desire to race on a super-speedway.
He will return to McLaren’s F1 outfit after the race and drive for the rest of the season, despite the disappointing package.
He follows in the slipstream of US driver Johnny Rutherford won the race in 1974 and 1976 driving a McLaren.