A slower paced second half saw England quite comfortable on the ball but not as eager as they were in the first half.
It was six on the hour mark, Harry Kane scoring with his heel, following Loftus-Cheek's deflected shot, as he scored in his last act, before being substituted.
Panama almost grabbed a consolation goal, through captain Torres, but he missed from yards out after the ball fell to him from the corner.
The Central Americans did have their goal, as Felipe Baloy got onto the end of a free-kick and prodded it home, sparking jubilant celebrations, despite the scoreline.
5 Things to take away from England v Panama
England need to deal with set pieces
Although a small dent into their win, England once again conceded from a set piece as Baloy scored Panama's goal.
Just like Tunisia's penalty, the two goals they've conceded are from dead ball situations. In their next game against Belgium, they must be alert.
Captain Kane for Golden Boot?
Harry Kane now has five goals at the World Cup, putting him in a superb position to grab the Golden Boot for the tournament. He's done it for Spurs but Kane is now doing it on the grand stage.
Despite being on the end of a 6-1 thumping, it was great to see the scenes of Panama on their first ever World Cup goal, the Central American minnows certainly enjoyed that goal.
The 25-year-old really stood up in this game and was fully deserving of his superbly taken goal.
Leaks? No problem.
Despite the team being leaked in an open training session, England kept the same team, other than a forced change in Alli for Loftus-Cheek. They were impressive today.