People voted 65% in favour of supporting an End of Life Choice Act that gives people with a terminal illness the option of requesting assisted dying.
The vote is the second referendum on independence in two years. Campaigners for separation from France feel victory this time is within their grasp.
Voters are expected to reject breaking away from France's control after almost 170 years despite rising support for the move.
Exit polls suggested a fairly resounding 'yes' vote won the day in the referendum with a projected share between 60-64%.
On her first visit to Brussels following Brexit, Scottish first minister Nicola Sturgeon insisted on Scotland's place in the European Union, as a sovereign independent state.
Her remarks were made during a speech at a Brussels-based think tank.
John Momis, president of Bougainville, was one of the first to vote on Saturday in a two-week referendum on independence from Papua New Guinea.
The 27 Brexit weary EU states met on Sunday and agreed they would forward a controversial letter from the British Prime Minister Boris Johnson to the European Parliament this week for approval.
With the clock ticking down to a no-deal Brexit, opposition parties have been launching rival plans to avoid a cliff-edge departure.
If he wins President Al Sisi could stay in power until 2030 and the role of the already powerful military would be boosted too.
Swiss voters rejected tax breaks for married couples by a slim margin, but the country's federal court has overturned the result, saying voters were not in full possession of the facts
Voters in New Caledonia have decided that the South Pacific islands should become remain as a French territory
A referendum was held on whether to change the law, which makes publishing or uttering a blasphemous comment punishable by a fine of 25,000 euros.