The pop star, who is known to suffer from fibromyalgia, said she was "devastated" to disappoint her fans. "I love you, but this is beyond my control," she said on Twitter.
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Lady Gaga has canceled 10 concerts in Europe because of severe pain, the tour's promoter said on Saturday.
Live Nation said the pop star is "suffering from severe pain that has materially impacted her ability to perform live."
The 31-year old singer-songwriter, whose real name is Stefani Joanne Angelina Germanotta, has spoken about suffering from fibromyalgia, a chronic pain disorder.
On Twitter, Lady Gaga said she was "devastated" to disappoint her fans. "I love you, but this is beyond my control," she said.
The singer-songwriter’s Joanne World Tour kicked off in Vancouver last August and was scheduled to end on February 23 in Berlin.
Lady Gaga was due to play this Sunday and next Thursday at London's O2 Arena.
The other canceled concerts were in Manchester, Zurich, Cologne, Stockholm, Copenhagen and Paris.
Ticket holders can get a refund starting next Tuesday (February 6), the tour promoter said.