President Joe Biden on Thursday served notice that America's war on COVID-19 is under new command with a set of executive orders.
In doing so he promised an anxious nation progress in reducing infections.
At the same time, he tried to manage expectations in his second day in office, saying despite the best intentions “we're going to face setbacks.”
He brushed off a reporter's question on whether his goal of 100 million coronavirus shots in 100 days should be more ambitious, a point pressed by some public health experts.
The 10 orders signed by Biden are aimed at jump-starting his national COVID-19 strategy to increase vaccinations and testing, lay the groundwork for reopening schools and businesses, and immediately increase the use of masks — including a requirement that Americans mask up for travel.
One directive calls for addressing health care inequities in minority communities hard hit by the virus.
“We didn’t get into this mess overnight, and it will take months to turn this around,” Biden said at the White House.
US deaths have surged past 400,000, and he noted projections that they could reach 500,000 in a month.
But then, looking directly into the TV camera, Biden declared: "To a nation waiting for action, let me be clear on this point: Help is on the way.”
The new president has vowed to take far more aggressive measures to contain the virus than his predecessor, starting with stringent adherence to public health guidance.
A key difference is that under Biden, the federal government is assuming full responsibility for the COVID response. And instead of delegating major tasks to states, he is offering to help them with technical backup and federal money.
He faces steep obstacles, with the virus actively spreading in most states, vaccine shortages, slow progress on distribution and political uncertainty over whether congressional Republicans will help him pass a $1.9 trillion economic relief and COVID response package.
Adding to the challenges are virus mutations, particularly one that has emerged in South Africa, that may make vaccines somewhat less effective.
Dr Anthony Fauci told reporters at the White House briefing that “we are paying very close attention to it.” Biden's plan includes an expansion of research capabilities to map out the genetic structure of new variants.