Manchester United will be missing injured duo captain Wayne Rooney and midfielder Morgan Schneiderlin for the club’s all-important Champions League game at Wolfsburg on Tuesday.
Rooney remains sidelined with an ankle injury while France international Schneiderlin was substituted late in the first-half of United’s Premier League match with West Ham after picking up a hip injury.
Michael Carrick is expected to deputise.
Boss Louis Van Gaal will also be without Phil Jones, Marcos Rojo and Ander Herrera for the final Group B tie against the leaders.
Second in the group, United must win to seal a last 16 spot.
United are one point ahead of Dutch side PSV Eindhoven, who have a superior head-to-head record having beaten the English Premier league side in the Netherlands and drawn 0-0 at Old Trafford.
PSV finish their group campaign against CSKA Moscow.
Ten-times champions Real Madrid have already qualified for the next phase as group A winners but will finish up with visit by eliminated Malmo while runners up Paris Saint Germain host Shakhtar Donetsk.
Atletico Madrid and Benfica have both made it out of Group C.
The pair square off in Lisbon to decide who wins the group while Galatasaray host Astana to see who plays the Europa League.
Manchester City have have already ensured their place in the last 16 and play Borussia Monchengladbach in their final game.
Last season’s losing finalists Juventus – who are two points clear of City at the top of the group – play their final group game at Sevilla.