The strikes, which damaged over 70 sites across the capital, caused severe destruction in the Sviatoshynskyi and Solomianskyi districts.
A missile hit a nine-story residential building in Sviatoshynskyi, flattening its entrance and trapping residents under the rubble. Four people died at the site.
Emergency crews worked through the morning to rescue survivors, including a man pulled from debris after five hours. At least nine children were among the injured.
Explosions were also reported in the Dnipro, Poltava, Sumy and Mykolaiv regions.