The two-time Olympic champion and Phoenix Mercury starter is facing up to 10 years in prison if convicted.
US basketball star Brittney Griner has appeared in court near Moscow on suspicion of possessing cannabis.
Griner was arrested in February at Moscow’s Sheremetyevo Airport while travelling to play for a Russian team during the US off-season.
The 31-year-old was finally brought before judges on Friday -- more than four months later -- to formally face drug possession charges in a behind-closed-doors trial.
Griner, a two-time US Olympic gold medalist, could face up to 10 years in prison if convicted.
The athlete’s detention and trial come amid heightened relations between Moscow and Washington following Russia's invasion of Ukraine.
Griner was arrested less than a week before Russia sent troops into Ukrainian territory.
Police said she was carrying vape canisters with cannabis oil through the airport and accused the basketball player of large-scale transportation of drugs.
On Friday, Kremlin spokesman Dmitry Peskov denied that politics played a role in Griner’s prosecution.
“The facts are that a famous athlete was detained in possession of prohibited medication containing narcotic substances,” Peskov told reporters. “In view of what I’ve said, it can’t be politically motivated.”
In May, the US State Department classified Griner as wrongfully detained and handed the case over to its special envoy for hostage affairs. Griner’s supporters have even encouraged a prisoner swap.
Griner’s wife, Cherelle, has urged President Joe Biden to secure her release, calling her “a political pawn”.
“It was good to see her in some of those images, but it’s tough," added Vanessa Nygaard, Griner's coach with the Phoenix Mercury.
"Every time’s a reminder that their teammate, their friend, is wrongfully imprisoned in another country."
"The US embassy and the country care deeply about this case," embassy representative Elisabeth Rood said outside the Russian court.
"[Griner] told me to convey that her spirits are high and that she is keeping the faith," Rood added.