Zlatan Ibrahimovic returns to his first club Malmo on Wednesday in a bid to help Paris Saint Germain qualify for the last 16 of the Champions League.
PSG are second in Group A behind leaders Real Madrid and will progress with victory in Sweden.
A draw could also be good enough for the French champions, providing Shakhtar fail to claim a home victory over Real Madrid.
After their crushing defeat at the hands of their bitter rivals Barcelona at the weekend Real will look to bounce back in style in Ukraine and progress as Group A winners.
Wayne Rooney has recovered from an illness and could feature as Manchester United look for a win against PSV Eindhoven that will send them through to the knockout stages.
Louis Van Gaal will be without the services of Antonio Valencia, Michael Carrick, Ander Herrera and Phil Jones for the Group B clash at Old Trafford but Anthony Martial is fit again and Marouane Fellaini is back from a calf injury.
Meanwhile CSKA Moscow will need to beat third placed Wolsburg in the Russian capital to keep alive their hopes of qualifying.
In Group C Benfica will book their last 16 ticket if they beat competition newcomers Astana. Atletico Madrid meanwhile need a single point from their tie with Galatasaray to qualify.
Last season’s finalists Juventus need a win against already-qualified Manchester City to advance from Group D. Sevilla have to beat eliminated Monchengladbach and hope Juve lose to have any chance of qualifying.