Protesters focus their anger on the President over the tragedy and are calling on Jimmy Morales to step down.
Grieving parents lay to rest another victim of the fire at a children’s shelter in Guatemala.
The number of girls killed in the tragedy has climbed to 39, with several still in a critical condition.
Anger over the deaths has been concentrated on the government, after it emerged the girls had been locked in a classroom when a fire broke out.
Thousands took to the streets of Guatemala City on Saturday, reading the names and ages of the dead girls.
President Jimmy Morales blamed the state-run institutions for the deaths and promised reforms. Pledges that fell on deaf ears at the protest, as many called on the leader step down.