Dozens were evacuated from the area, with the drone strikes damaging a hospital and other civilian infrastructure.
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At least seven people have been injured in a Russian overnight drone attack on Ukraine's Kharkiv region, medical officials said on Saturday.
The attack damaged a medical facility, residential buildings, shops and other civilian infrastructure facilities.
Rescuers and volunteers worked to clear debris after the assault.
Local authorities report that one of the drones hit a three-story medical facility, causing a fire on the roof.
Rescuers evacuated at least 64 people from the building, including 56 patients and a child, officials said.
The Kharkiv Regional Prosecutor's Office reports that two six-year-old children were among the wounded.
Regional governors reported further Russian attacks in Zaporizhzhia, Donetsk, Sumy, Odesa, Cherniv, Cherkasy and Kyiv, according to Ukrainian media.
154 Shahed-type drones were launched against Ukraine overnight, Ukraine's Air Force said, with 103 reportedly being shot down and 51 lost without causing damage.
The on-the-ground attacks come as Ukrainian President Volodymr Zelenskyy travels to the United Kingdom for talks with UK Prime Minister Keir Starmer for talks ahead of a crisis summit of European leaders on Sunday.