Rafael Nadal has been forced to withdraw from two US Open warm-up events because of a wrist injury.
The Spaniard sustained the injury during practice and will have to wear a cast on his right wrist for two-to-three weeks, meaning he will miss the Rogers Cup in Toronto and the Cincinnati Open.
Nadal, the world number two, won both titles last year on his way to winning at Flushing Meadows. Competition in New York starts on August 25.
“I’m extremely disappointed that I am unable to defend my Rogers Cup title this year,” the 14-time grand slam winner said in a statement released by the tournament organisers.
Nadal’s withdrawl means two-times grand slam champion, Britain’s Andy Murray will move into the number eight seed, giving him a first round bye.