After a consolatory pat on the back by teammate Michael Rogers, Tour de France contender and two time champion Alberto Contador withdrew from this year’s edition.
The Spaniard tried to continue after crashing on stage ten but the pain was too much and scans later revealed he had suffered a fractured tibia.
As Contador became the third former champion to withdraw following Chris Froome and Andy Schleck the race continued out in front.
Former race leader and now hot favourite for the title, Vincenzo Nibali, had been content to let an early breakaway including Thomas Voeckler, Joaquim Rodriguez and Peter Sagan get clear.
But as the 161.5km trek to La Planche des Belles Filles drew to a close Nibali made his move.
The Italian timed his ride to perfection to sweep up the final escapee Rodriguez on the final climb.
With just over a kilometre of the stage to go Nibali was plain sailing and eventually crossed over for a solo win.
It was a double victory for the Astana rider who also reclaimed the leaders yellow jersey.
Frenchman Thibaut Pinot of the FDJ.fr team took second place while Spain’s Alejandro Valverde of Movistar rounded off the podium.
After loaning the yellow jersey to Frenchman Tony Gallopin for Bastille Day, Nibali is back in control and holds a two minute and 23 second lead over Aussie rider Richie Porte.