Spain go into their Group C Euro 2016 qualifier with Luxembourg looking for the win which will see the side book passage for the tournament in France.
On paper the result appears a forgone conclusion against the minnows from Luxembourg.
Real Madrid’s Sergio Ramos is out through injury and Diego Costa is suspended.
The international marks a landmark for Spain as it will become the country’s 150th Uefa European championship fixture.
In the rest of Group C Slovakia, already sure of a play-off place, entertain Belarus looking to keep their noses in front of Ukraine who take on FYR Macedonia.
In Group E England, already into the finals in France, will be captained by Chelsea defender Gary Cahill when they take on Estonia at Wembley. Regular captain Wayne Rooney is out with an ankle injury picked up in Man United’s defeat at Arsenal last Sunday.
Group G leaders Austria have been in superb form and have already booked their place in France for 2016.
Austria travel to Montenegro. Russia are in second spot eight points behind the Austrians. Russia play Moldova.