Cristiano Ronaldo is one goal short of former Real Madrid striker Raul’s all-time record of 71 Champions League strikes when the Spanish defending champions take on Liverpool at the Santiago Bernabeu in Group B on Tuesday.
Gareth Bale meanwhile should return following a buttock injury as Carlo Ancellotti’s group-topping side look to secure their place in the knockout stages with a win.
Despite travelling to Madrid Liverpool’s Daniel Sturridge is unlikely to make a comeback having been out of action since September with thigh and calf injuries.
Mamadou Sakho and defender Jon Flanagan remained sidelined both suffering with knee injuries as the Reds look to get their season back on track following a poor run of form.
Liverpool lost the reverse fixture 3-0 but fortunately for Brendan Roger’s men, like Ludogorets and Basel who also play each other on Tuesday, have three points and cannot be eliminated by defeat.
In Group A after two consecutive defeats Italian champions Juventus will look to get back to winning ways when they host Olympiacos in Turin. Leaders Atletico Madrid travel to Malmo.
Group C leaders Bayer Leverkusen will move closer to the last 16 with victory in Saint Petersburg while Monaco will hope to boost their chances to progression when they visit Benfica.
If Arsenal and Borussia Dortmund win their respective games against Anderlecht Galatasaray both will advance to the knockout stage with two matches remaining.