Amanda Knox and Raffaele Sollecito are back on trial in Italy for the murder of 21-year-old student Meredith Kercher in 2007.
They were convicted in 2009 and acquitted in 2011.
The Italian Supreme Court ruled that the case should be tried again, ruling that the acquittal jury did not consider all the evidence.
Lawyer Francesco Maresca, who represents Kercher’s family, told reporters: “We have always maintained that they are guilty and that they were present at the crime scene. And we think the that the Supreme Court asking for this retrial also points in that direction.”
Knox, who returned home to the US when she was acquitted, is not planning to attend the retrial in Italy.
Legal experts are divided over whether Italy could have her extradited or not.
As the retrial began, Sollecito’s father Francesco Sollecito told journalists: “A deeper examination cannot but confirm what we already know – that Raffaele had nothing to do with what poor Meredith Kercher had to suffer.’‘
The original trial focused on the theory that Knox and Sollecito had killed Kercher in a drug-fuelled sexual assault. One person, Rudy Guede, remains in prison for the murder.
Knox and Sollecito have always maintained their innocence.