Wayne Rooney scored a brace to reach the 200 goal mark for Man United while Robin Van Persie and Antonio Valencia added their names to the scoresheet as the three times champions beat Bayer Levekusen 4-2 in their Champions League group A opener.
The hosts opened their account in the 22nd minute with a Rooney volley before Leverkusen captain Simon Rolfes levelled after 54 minutes.
Van Persie put the former English Premier League champions ahead again five minutes later with an acrobatic volley:
Rooney made the elite club of four players to reach 200 goals for the Red Devils with a left-footed effort on the 70th minute.
Valencia put the game into safe territory for United nine minutes later before Omer Toprak’s late strike for Leverkusen gave the visitors a glimmer of hope.
But it was too little too late for the Bundesliga side as United’s David Moyes enjoyed his first taste of managing in the Champions League group stage with a victory.
Elsewhere in the group Shakhtar Donetsk beat Real Sociedad.
Cristiano Ronaldo scored a hat-trick and Karim Benzema a brace to help nine-time champions Real Madrid demolish Galatasaray 6-1 in their Group B opener.
Isco completed the scoring for the Spanish giants.
Juventus meanwhile came from behind to share the spoils with FC Copenhagen in a one all draw in Denmark.
Big Spending Paris Saint Germain safely negotiated their first european test this season when Thiago Motta scored twice, and Marquinhos and Edinson Cavani also hit the mark in a 4-1 win over
Also in Group C Benfica kick-started their campaign with a 2-0 win over Anderlecht.
David Alaba, Mario Mandzukic and Arjen Robben all scored as Bayern Munich began their title defence with a flawless 3-0 home win over CSKA Moscow.
Bayern are attempting to become the first team since AC Milan in 1990 to win the European trophy in back-to-back seasons.
They got off to a dream start when Alaba floated a vicious free kick into the back of the net in the third minute.
Croat Mandzukic added a second goal just before the break, heading in an Arjen Robben free kick.
The Dutchman got his own name on the scroesheet midway through the second half to make 3-0 and hand new coach Pep Guardiola – who won the title with barcelona – a successful return to the competition.
Elsewhere in the group Edin Dzeko, Yaya Toure and Sergio Aguero scored in a ten minute period to hand Manchester City a 3-0 victory over Viktoria Plzen.