Spanish giants Real Madrid will be seeking to bounce back from their disappointing 1-0 loss to Sevilla in La Liga when they open their Champions League campaign against Manchester City on Tuesday.
Coach Jose Mourinho has a fully fit squad to pick from while Brazil defender Maicon may make his debut for City as Micah Richards and Pablo Zabaleta are yet to recover from injuries.
This will be the first competitive meeting between these two sides.
In group B, Arsenal will lock horns with Montpellier at the stade de la Mosson.
The Gunners, who are currently unbeaten in the Premier League this season, will be without first-choice goalkeeper Wojciech Szczesny because of an ankle problem while Montpellier coach Rene Girard will welcome back both Mapou Yanga-Mbiwa and Remy Cabella after resting them at the weekend.
Elsewhere, AC Milan coach Massimiliano Allegri has urged his players to step it up a gear as the Italians get ready to face Anderlecht.
The Rossoneris, who slumped to a 1-0 loss to Atalanta on Saturday will be without Robinho and Alexandre Pato while the Belgian side will have to make do without the services of Milan Jovanovic who is suspended.
In group C’s other game, Malaga will make their first appearance in the Champions League group stages when they face Russian side Zenit St Petersburg at the Rosaleda.