Hundreds of demonstrators stormed the U.S. embassy in the Yemeni capital, Sanaa, on Thursday.
Security guards fired into the air to scare the protesters away but they forced themselves through the main gate of the heavily fortified compound.
The protesters also torched a number of vehicles outside the building’s perimeter.
Witnesses at the scene said live rounds were fired, but there were no immediate reports of casualties or fatalties.
It follows two days of protests across the Muslim world over an American-made amateur film deemed to be insulting to Islam.
It pokes fun at the Prophet Muhammad and portrays Muslims as violent and immoral.