Turkey on Wednesday imposed sanctions on Syria over its crackdown on anti-regime protesters.
The Turkish government was once one of Syria’s closest allies but it has stepped up its criticism of President Bashar Assad in recent weeks.
Turkish Foreign Minister Ahmet Davutoglu said Assad’s government had “squandered every last chance” that it had been given.
He said Assad’s rule had reached “the end of the road.”
The sanctions include asset freezes and travel bans on senior Syrian officials.
Ankara will also halt relations with Syrian state banks and ban deliveries of military equipment to the country.
The United Nations estimates at least 3,500 people have died since the uprising began in March.