High-flying Bayern Munich host tournament debutants Manchester City on matchday two of the Champions League on Tuesday night in Group A.
The Germans who have won their last nine games in all competitions without conceding a goal, could be without influential central defender Holger Badstuber through illness.
Daniel van Buyten, who scored against Bayer Levekusen at the weekend is the likely deputy.
While Bayern got their European campaign off to a winning start against Villarreal Roberto Mancini’s men drew at home with Napoli.
The Italian will be without the suspended Mario Balotelli, Owen Hargreaves who has not been registered for Europe so will not face his former club and winger Adam Johnson through injury.
Elsewhere in the group Napoli and Villarreal square up in Italy hunting their first victory of the new campaign.
Trabzonspor will look to continue their winning start to group B when they host French champions Lille while CSKA Moscow entertain an out-of-sorts Inter at the Luzhniki Stadium.
Squad rotation appears to be the flavour of day again for Manchester United who welcome FC Basel to Old Trafford
With Wayne Rooney and Javier Hernandez out through injury Alex Ferguson should be looking towards the likes of Dimitar Berbatov, Michael Owen and Danny Welbeck to rise to the occasion.
Also in Group C Benfica, who were held to a one all draw with United in the group opener a fortnight ago, travel to Bucharest and Romanian champions Oţelul Galaţi.
Nine times European winners Real Madrid host Ajax in Group D.
Coach Jose Mourinho completes the last game of his three-match ban and will watch from the stands as his side tackle the former European powerhouse who haven’t won a match in their last three outings.
Nonetheless defender Alvaro Arbeloa wasn’t taking his opponents lightly and said: ‘‘I do not think it’s a worse team, they might have lost a couple of important players but as a whole they have won things and they have got a couple of players although not well know, but very skilful and their talent will show in the next few matches.’‘
Completing the round of matches in Group D are champions league regulars Lyon who host the Croatians of Dinamo Zargreb.