Human rights activists say hundreds of thousands of Syrians have demonstrated after Friday prayers calling for an end to the regime, despite ongoing repression by the authorities.
In the city of Deir al Zour in the east of the country more than 400,000 reportedly took to the streets.
Protests have taken place in several cities around the country. Many people wanted to show solidarity with Homs, where the crackdown has been particularly violent.
Activists say many people are living in fear of abritrary arrest following large numbers of detentions in recent weeks.
The Syrian Human Rights League said security forces were deployed in considerable numbers in at least two districts of Damascus.
Phone lines and electricity were reportedly cut in two areas outside the capital.
The regime, which has banned almost all foreign media, has come under massive international criticism.
On Thursday hundreds of Syrian expatriates demonstrated in the Jordanian capital Amman. They chanted slogans and held up photos of alleged victims.
They also accused international organisations of failing to respond adequately. The Arab League in particular has been criticised for sitting on the fence.
Huge rallies in Syria show solidarity wtih Homs