At least 15 people died during protests close to Israel’s borders with Syria, Lebanon and the Palestinian territories on Sunday.
Palestinians and their supporters were protesting against the establishment of Israel in 1948.
At the disputed Golan Heights, close to the Syrian border, dozens of demonstrators crossed into the Israeli-held territory to be met by live gunfire.
At least four people were killed and scores more were injured. Syria called Israel’s response “a criminal act.”
Israel captured the Golan Heights from Syria in the 1967 Six-Day War. Syria is home to over 450,000 Palestinian refugees.
Violence also flared during protests on the Israeli-Lebanese border.
Lebanese security sources told Reuters that 10 people died when Israeli forces fired at demonstrators trying to cross into Israel.
The same sources said more than 100 people had been wounded.
Medical sources in the Gaza Strip said one Palestinian died and some 30 were injured in the Gaza Strip when Israeli tanks fired at demonstrators.
An Israeli military spokesman accused Tehran of orchestrating the unrest, branding it an “Iranian provocation.”
Palestinians call Israel’s creation the ‘Nakba’, or the catastrophe, owing to the hundreds of thousands of people displaced when the Jewish state was founded.
They want East Jerusalem as their capital of a future state which include the West Bank and Gaza.