It has been a rare, very public falling out among powerful Russian politicians in the same ruling party.
The 18-year reign of Yuri Luzhkov as mayor of Moscow has come to an abrupt end, sacked by President Dmitri Medvedev.
The sacking came after weeks of tension.
“The reason stems from a special decree,” said President Medvedev during a trip to China. “As the President of the Russian Federation, I lost my confidence in Yury Luzhkov as the mayor of Moscow.”
The Russian constitution gives the president the power to sack the Moscow mayor and regional governors at will, and elections are not required.
74-year-old Luzhkov is reported to be planning a news conference to respond to his sacking.