Israel has announced it is closing off the West Bank from midnight Sunday until April 6.
Security concerns have been given as the reason, as Israel begins to mark the week-long Jewish Passover holiday.
Only those given exemptions will be allowed to go through checkpoints.
Tension is high in the region with clashes and demonstrations in a row over Israeli settlement building.
Meanwhile, the Israeli Prime Minister has warned militants the army will respond to any attacks from the Gaza Strip that harm Israelis.
This follows deadly clashes along the Hamas-run territory’s border.
Benjamin Netanyahu issued his warning at the start of a weekly cabinet meeting.
Two Israeli soldiers and two Palestinian militants were killed on Friday.
This was the most deadly clash on the Israel-Gaza border since Israel ended an offensive there 14 months ago.