US Secretary of State Hilary Clinton has met Russian Foreign Minister Sergei Lavrov for talks in Moscow on nuclear disarmament.
The Middle East and Iran were high on the agenda alongside the nuclear issue.
Lavrov told reporters both countries were close to the “finish line” in signing a new agreement to reduce their nuclear stockpiles.
The treaty will replace a 1991 accord, which expired last December.
It marks part of Washington’s bid to improve relations with Moscow.
Secretary Clinton, however, acknowledged some disagreements still remained.
“There are differences in our relationship, we know that, we raised them and we have had very frank conversations about them,” she said. “But they are raised within a context of an overall approach that looks for ways to narrow the areas of difference and disagreement.”
US-Russia ties were strained under former President George W Bush, with Moscow especially angry at a planned anti-missile shield in Poland and the Czech Republic. Obama scrapped that plan in September but later announced a scaled-down version of the project to be located in Romania.